When monitoring a Web site, you need to look at it both from a 'micro' perspective (i.e. are the individual devices and servers in your infrastructure running smoothly?) and from a 'macro' perspective (i.e. do your customers have a pleasant experience when accessing and using your site?; can they use your site's functionality to conduct their business online?). You can also think about these types of monitoring as 'engineering' monitoring vs. 'business' monitoring.
